Here are the Innovations available for the 2027 CASCADE program
To learn more about the CASACDE program and application details, please visit CASCADE landing page.
Medical Devices
Smartphone-Enabled Optical pH Imaging for Cavity Prevention (BDP 7425)

A smartphone-enabled imaging platform that creates quantitative maps of dental plaque acidity to help identify cavity risk before tooth damage occurs. The technology enables low-cost, non-invasive monitoring in both home and dental care settings.
EasyAir: Self-Navigating Emergency Airway Device (BDP 8049)

A self-navigating emergency airway device that uses soft robotics to simplify airway placement, reducing training requirements and enabling faster respiratory support in emergency and battlefield settings.
Simpl-E-Vac: Ready-to-Use Endoscopic Vacuum Therapy for Gastrointestinal Leaks (BDP 8617)

A ready-to-use endoscopic vacuum therapy (EVT) system that enables faster, standardized treatment of gastrointestinal leaks using existing hospital infrastructure, eliminating the need for clinician-built devices.
Meta-Optic Ultrathin Catheter Endoscopes for Image-Guided Interventions (BDP 8841)

An ultrathin, flexible endoscope that uses meta-optics and computational imaging to enable visualization deep within narrow, tortuous blood vessels. Designed to improve image-guided stroke and cardiovascular interventions where conventional endoscopes cannot reach.
Noninvasive Ultrasound Treatment for Feline Urinary Stones (BDP 8524)

A noninvasive ultrasound-guided therapy that breaks urinary stones into passable fragments, offering an alternative to surgery for cats with ureteral obstructions. The technology combines real-time imaging and targeted stone treatment in a single procedure to reduce risk, recovery time, and treatment burden for feline patients.
Wearable Ultrasound Sensor for Continuous Lung Fluid Monitoring (BDP 8774)

A low-cost, wearable ultrasound sensor that continuously monitors lung fluid buildup without requiring imaging specialists or repeated scans. The technology enables automated, hands-free detection of pulmonary congestion for patients with heart failure and other cardiac or respiratory conditions.
Hardware
Acousto-Optic Beam Steering (BDP 8032)

This integrated photonics platform steers laser beams electronically on a tiny chip, reducing size and power requirements while enabling next-generation sensing, imaging, and communication systems.
Freeform Direct-Write and Rewritable Photonic Integrated Circuits (BDP 8875)

This direct-write photonics platform creates rewritable optical circuits on demand, enabling rapid design iteration, programmable photonic systems, and lower-cost development of next-generation optical technologies.
Clean tech
Scalable Heavy-Atom-Free Photon Upconversion Systems for Solar Energy Applications (BDP 8325)

This energy conversion system upconverts otherwise wasted near-infrared light to the visible spectrum, helping increase solar cell efficiency through scalable, non-toxic materials compatible with commercial manufacturing processes.
Battery-Free Tree Sensors for Power Line Wildfire Prevention (BDP 9077)

This battery-free monitoring platform uses tree-embedded sensors to track vegetation growth and detect wildfire risks in real time, enabling proactive management of utility transmission corridors.
PFASPure: PFAS-Selective Water Filtration Media (BDP 9124)

A drop-in water treatment media that enhances capture of emerging PFAS contaminants using molecularly imprinted polymers, helping utilities meet evolving regulations while leveraging existing carbon filtration systems.
Agentic AI
VersarAI Policy Controls for AI Agents (BDP 9108)

VersarAI provides a policy-aware personalization layer for AI agents, helping enterprises apply organizational rules consistently while adapting agent behavior to user-specific needs and preferences.
Health tech
Digital Health Platform for Patient Activity Support and Clinical Decision Support (BDP 8055)

A digital health platform that integrates wearable and mobile device data with clinical workflows to help patients increase physical activity and enable providers to deliver personalized, data-driven care between visits.
Multi-Omic Single-Cell Platform for Genetic and Epigenetic Discovery (BDP 9280)

A single-cell analysis platform that simultaneously measures DNA sequence, DNA methylation, and gene expression from the same cell. The technology enables researchers to directly connect genetic changes to cellular behavior at unprecedented resolution and scale.
Early Biopsy-Free Liver Cancer Diagnosis on Existing Ultrasound Scanners (BDP 9290)

This ultrasound technique briefly shuts off blood flow only inside tumors, so they show up as dark voids. Suspicious liver lesions can be confirmed during the scan, catching cancer while it’s still curable.
Long-Read DNA Sequencing for Precision Relationship and Ancestry Detection (BDP 9343)

A long-read sequencing and bioinformatics platform that improves detection of biological relationships and ancestry without relying on population reference databases. The technology enables higher-resolution identification of distant genetic relatives across diverse populations.
HRDefine: A Clinical Test to Expand Treatment Options for Ovarian and Triple-Negative Breast Cancer Patients (BDP 9212)

HRDefine is a diagnostic test designed to identify ovarian and triple-negative breast cancer patients who may benefit from poly (ADP-ribose) polymerase (PARP) inhibitor therapy, including patients who may be missed by current testing methods. By providing a more complete picture of tumor biology, it has the potential to expand access to targeted therapies and help guide more personalized treatment decisions.