Summer 2025
Dendrimer Nanomedicine for TBI | We have developed a simple and effective nanoparticle-based system that can deliver medicine directly to neurons in the brain, even across the protective blood-brain barrier. This system uses a sugar-modified carrier to find and enter the right brain cells at the site of injury, making treatment more precise. Our method is easy to reproduce and scalable, offering a promising path for future brain disease therapies.
DeNovoAgonists | Native growth factors and cytokines have limited clinical success due to poor stability and high promiscuity. Our platform technology produces protein-based agonists that are highly stable, active, and specific for their targets, with promising studies in cells and mice. We will explore their applications in treating diseases that currently lack effective therapies while developing new agonists using our platform.
Error Disclosure Simulator | Our software is an interactive AI conversational agent that simulates realistic patient responses to a physician disclosing a harmful medical error. Using speech-to-text and text-to-speech technology, the AI interface allows users to speak naturally with a simulated patient drawn from a case library or a custom-built scenario. The AI model evaluates communication skills and provides real-time, personalized recommendations to improve empathy, information sharing, and overall disclosure efficacy.
Godel EdgeAI | Godel Space provides AI-native platforms deployed on satellites and edge devices to rapidly convert satellite imagery into actionable insights. Our solution supports applications such as post-disaster monitoring, infrastructure resilience, and defense intelligence. The technology leverages advanced foundation models and edge computing to deliver real-time situational awareness.
InnoMat.AI | InnoMat.AI is an AI-powered platform revolutionizing materials innovation by integrating material discovery, behavior simulation, and supplier intelligence into a seamless digital experience. Our solution enables R&D and supply chain teams to identify optimal materials, simulate performance virtually, and connect with verified suppliers—all within one cloud-native environment. Built on Microsoft Azure, our platform reduces prototyping costs, accelerates time-to-market, and ensures technical rigor across the innovation lifecycle.
Microvia | Bacteria offer a promising, cost-effective alternative to human live-cell cancer immunotherapies due to their ability to colonize tumors and thrive in the tumor microenvironment. We are engineering a nonpathogenic E. coli strain that can detect solid tumors and secrete therapeutic payloads for immunotherapy.
Mini MMG | Caregivers of patients receiving neuromuscular blocking drugs need a low-cost, effective way to measure the level of neuromuscular block to detect residual blockade, especially in institutions that cannot afford existing solutions. We have developed a device that measures the level of neuromuscular blockade by detecting the force exerted by the abductor pollicis brevis muscle in response to ulnar nerve stimulation. This device will help caregivers accurately monitor and manage neuromuscular block levels.
pHastCam | Our solution uses low-cost components, including a 3D-printed integrating sphere with LED lights, pH sensors created from a pH-sensitive dye, and a smartphone camera to analyze blood pH. Current blood pH devices are expensive and often inaccessible, yet blood pH is an important indicator of complications during birth in infants. Our design combines software-based image analysis with digital number evaluation to determine pH efficiently and affordably.
TheraGland | We create human iPSC-derived salivary gland organoids that are highly scalable and easily modified to model disease conditions. This system is ideal for high-throughput pharmaceutical screening to test therapeutic efficacy in treating salivary gland disease and to identify potential side effects of pharmaceuticals on salivary function.
Therapeutic Bubble Tea | Thera-T bubbles act like mobile, compartmentalized “mini-dialysis machines” that can be safely ingested. They move through the GI tract using natural peristalsis while reducing toxin concentrations and are excreted safely from the body, eliminating the need for invasive dialysis devices. Delivering these hydrogels in a patient-friendly bubble tea drink offers a less physically and psychologically draining alternative to traditional dialysis treatments.
Treatment of Overuse Injuries | We address two main challenges for patients with lower-limb overuse injuries: extended recovery time and re-injury upon returning to activity. Our innovation is an auto-adjusting brace that treats injuries while patients go about daily activities, monitors key biomechanical metrics, and enables telehealth communication for remote brace adjustments. Integrating this technology into clinical practice reduces costs and improves outcomes compared to current standards of care.
UWave Radio FM Expansion | The “UWave Radio FM Expansion Project” will add a low-power FM signal at 105.7 FM in Bothell to our existing internet radio station. Students successfully obtained this frequency from the Federal Communications Commission (FCC) in 2024. This project provides UW Bothell with a unique opportunity to create a community-building platform and enhance student-led communication through an expanded radio presence.
Vitalink | Vitalink is a wearable vital sign monitor that measures and characterizes multiple parameters, triggering tiered alarms based on different stages of patient distress that may occur during various activities.
Zukan Studio | Zukan Studio provides high-quality scientific illustrations, as well as animated and interactive digital graphics and websites for researchers and laboratories. These visual assets can be used for publications, posters, and presentations throughout the research lifecycle, helping clients effectively communicate and showcase their work.
Fall 2025
Life Science Teams:
Anti-Adhesin Miniproteins | Bacteria often use molecular grappling hooks called adhesins to adhere to cellular and other surfaces at the site of infection. To overcome the limitations of existing anti-adhesin therapeutic development strategies, namely the lack of knowledge of adhesin ligands and the difficulty raising antibodies to neutralizing epitopes, we’ve designed de novo miniprotein binders to the substrate binding pockets of adhesins implicated in both uncomplicated and catheter-associated urinary tract infections (UTI). These miniproteins show promise in preclinical murine models of UTIs.
Anti-thrombotic molecules | Currently available blood thinners have the risk of bleeding, which can be life threatening such as intracranial bleeding. We want to discover a drug that treats thrombosis while maintaining hemostasis. We are approaching this by targeting the blood clotting protein von Willebrand factor selectively under infalammatory conditions.
CascadeDx | Despite remarkable advances in prevention and treatment, global efforts to end the HIV epidemic are obstructed by structural inequalities, inconsistent access to care, and ineffectual treatment choices leading to drug resistance. A yet unrealized point-of-care test for drug adherence that is accurate, rapid, and did not require sophisticated laboratory equipment would enable health-care providers to tailor individual patient treatment, during their visit, reducing viral resistance, and unnecessary loss of life. To meet this important and missing need, CascadeDx has developed the EMERALD drug adherence assay: a simple, accurate, 10 minute test that covers all therapeutical relevant conditions and has application to other disease treatments for Hepatitis B/C, Cytomegalovirus, Herpes simplex, Shingles, and some cancers.
Cold Plasma Wound Care | We are developing a portable Cold Atmospheric Plasma (CAP) device that delivers highly uniform plasma to wound surfaces, overcoming the uneven distribution seen in current technologies. By generating therapeutic levels of reactive oxygen and nitrogen species (RONS), the device accelerates wound healing, reduces infection risk, and modulates inflammation without harming healthy tissue. This innovation integrates advances in power electronics and electrode design to create a clinically viable, non-invasive tool for treating chronic wounds and combating antimicrobial resistance.
De novo designed therapies | We’re using AI to build smarter, more effective medicines. We find diseases that are tough to treat and use technology to create new therapies that work better than traditional ones, tackling major problems in health.
Efficover | Efficover speeds up the insurance work dental clinics already do by quickly running coverage checks, explanations of benefits, and other correspondence in the background. Our system makes it easier for staff to spot mislabeled items, catch problems early, and know the next steps when contesting a claim. This helps patients avoid surprise bills while giving clinics a smoother, faster path to payment.
Elevanse | Our device, Vanta, is a self-inserted, inflatable, disposable solution for treating pelvic organ prolapse that conforms to a woman’s anatomy to provide customized, comfortable support. Designed to address the limitations of traditional pessaries, Vanta is inserted like a tampon using a simple applicator, then gently inflates to lift prolapsed organs, eliminating the need for cleaning, fitting, or clinical visits.
All Stem Teams:
AI4Curb | Using AI and standard dashcam street view footage to create detailed maps including lane-level road markings and roadside asset information for cities to optimize their plan and design.
CacheWave | CacheWave creates a new Content Delivery Network using AI-orchestrated distributed Edge node clusters. These nodes are on/near user-premise and offer ability to do content caching and compute offload. This approach saves significant amount of cost and energy, reduces latency and bandwidth overhead, and enables high performance streaming, rendering and computation at edge as compared to current offerings.
Guided Interactions | Guided Interactions is an intelligent platform that equips law enforcement with a standardized framework for responding to sensitive incidents like domestic and sexual violence, by guiding them through dynamic digital reporting and evidence based real-time procedural guidance. Our platform uses a logic engine to identify high-lethality risk factors and recommend critical actions, while simultaneously facilitating trauma-informed communication coaching, immediate “warm referrals” that connect victims to a live network of nearby support services and an on-demand AI for policy and legal questions. This system builds officer ‘muscle memory’ for best practices, ultimately reducing agency liability, removing barriers to victim support, and strengthening community trust through a more consistent and equitable response
MultiSensKnit | Our innovation is a smart sleeve that can sense muscle activity, joint motion, and other body signals all at once. It works like a “fitness tracker in your clothing,” giving doctors and patients real-time information about rehabilitation progress without bulky equipment. This makes recovery at home easier, more accurate, and more personalized.
NetSimulation as a Service | We offer network simulation service for telecommunications researchers and engineers. With just a Chrome browser, users can launch high-fidelity network simulation and view the simulation results interactively. Scalability is enhanced by the cloud-based simulation engine that leverages multiple CPUs.
NexTAGE | introduces a revolutionary three-component ecosystem: Agents, Assistants, and Sims. The core innovation lies in the Sims technology, which creates multiple, evolving digital representations of users that capture different life contexts. The combination of Assistant(s) and Sim(s) creates a digital twin for a given task and context that can carry out a personal and complex informational task such as planning, scheduling, or shopping without compromising on privacy or security.
S-BOMM Modelling (AI or otherwise) is extremely important for engineering and business decisions, but knowing which model to trust is nearly impossible. Set-Based Optimization with Multiple Models, or S-BOMM is a flexible technology for decision making with multiple models when the ground truth is unknown. S-BOMM deciphers the best route forward when models disagree, making engineering and business decisions easier and more likely to succeed.
Salino Researchers | need to know the salinity of the ocean in order to draw conclusions about coastal health, biology, and the impacts of climate change. To date, these measurements could only be done with costly instruments ranging from $2,000 to $15,000 – requiring manned deployments, high power connections, and thus preventing spatially resolved data from being collected. Salino costs less that $100 and can be run from an Arduino, and is yet accurate enough for many of the scientific measurements needed – making it the “purple air” solution for oceanography.
Xyntra | Improve ability of employees to protect themselves from emerging GenAI driven phishing threats.Autonomous anti-phishing testing and training solution leveraging large language models and optimization methods. Enterprise solutions for human risk management.